GiziLink Journals & Papers
Discover, read, and publish research papers and articles.
Publish Paper
Share your research with the world and get +50 Vita Credit.
Navigation
Personalized Nutrition Through the Gut Microbiome in Metabolic Syndrome and Related Comorbidities
Background: Metabolic syndrome, a clinical condition defned by central obesity, impaired
glucose regulation, elevated blood pressure, hypertriglyceridemia, and low high-density
lipoprotein cholesterol across the lifespan, is now a major public health issue typically
managed with lifestyle, behavioral, and dietary recommendations. However, “one-size-ftsall” recommendations often yield modest, heterogeneous responses and poor long-term
adherence, creating a clinical need for more targeted and implementable preventive and
therapeutic strategies. Objective: To synthesize evidence on how the gut microbiome can
inform precision nutrition and exercise approaches for metabolic syndrome prevention
and management, and to evaluate readiness for clinical translation. Key fndings: The gut
microbiome may influence cardiometabolic risk through microbe-derived metabolites and
pathways involving short-chain fatty acids, bile acid signaling, gut barrier integrity, and
low-grade systemic inflammation. Diet quality (e.g., Mediterranean-style patterns, higher
fermentable fber, or lower ultra-processed food intake) consistently relates to more favorable microbial functions, and intervention studies show that high-fber/prebiotic strategies
can improve glycemic control alongside microbiome shifts. Physical exercise can also modulate microbial diversity and metabolic outputs, although effects are typically subtle and may
depend on baseline adiposity and sustained adherence. Emerging “microbiome-informed”
personalization, especially algorithms predicting postprandial glycemic responses, has improved short-term glycemic outcomes compared with standard advice in controlled trials.
Targeted microbiome-directed approaches (e.g., Akkermansia muciniphila-based supplementation and fecal microbiota transplantation) provide proof-of-concept signals, but durability
and scalability remain key limitations. Conclusions: Microbiome-informed personalization
is a promising next step beyond generic guidelines, with potential to improve adherence
and durable metabolic outcomes. Clinical implementation will require standardized measurement, rigorous external validation on clinically meaningful endpoints, interpretable
decision support, and equity-focused evaluation across diverse populations.
glucose regulation, elevated blood pressure, hypertriglyceridemia, and low high-density
lipoprotein cholesterol across the lifespan, is now a major public health issue typically
managed with lifestyle, behavioral, and dietary recommendations. However, “one-size-ftsall” recommendations often yield modest, heterogeneous responses and poor long-term
adherence, creating a clinical need for more targeted and implementable preventive and
therapeutic strategies. Objective: To synthesize evidence on how the gut microbiome can
inform precision nutrition and exercise approaches for metabolic syndrome prevention
and management, and to evaluate readiness for clinical translation. Key fndings: The gut
microbiome may influence cardiometabolic risk through microbe-derived metabolites and
pathways involving short-chain fatty acids, bile acid signaling, gut barrier integrity, and
low-grade systemic inflammation. Diet quality (e.g., Mediterranean-style patterns, higher
fermentable fber, or lower ultra-processed food intake) consistently relates to more favorable microbial functions, and intervention studies show that high-fber/prebiotic strategies
can improve glycemic control alongside microbiome shifts. Physical exercise can also modulate microbial diversity and metabolic outputs, although effects are typically subtle and may
depend on baseline adiposity and sustained adherence. Emerging “microbiome-informed”
personalization, especially algorithms predicting postprandial glycemic responses, has improved short-term glycemic outcomes compared with standard advice in controlled trials.
Targeted microbiome-directed approaches (e.g., Akkermansia muciniphila-based supplementation and fecal microbiota transplantation) provide proof-of-concept signals, but durability
and scalability remain key limitations. Conclusions: Microbiome-informed personalization
is a promising next step beyond generic guidelines, with potential to improve adherence
and durable metabolic outcomes. Clinical implementation will require standardized measurement, rigorous external validation on clinically meaningful endpoints, interpretable
decision support, and equity-focused evaluation across diverse populations.
Jurnal
Peer-Reviewed
Burnout, Nutrition, and Nutrition Literacy or Food Literacy: A Scoping Review of Recent Peer-Reviewed Publications
Artikel ini merupakan scoping review yang mengkaji hubungan antara burnout, nutrisi, dan literasi gizi/pangan dalam publikasi peer-reviewed tahun 2020–2025. Peneliti menemukan bahwa pandemi COVID-19 mempengaruhi pola makan dan tingkat burnout secara signifikan. Salah satu temuan menarik: pada penderita diabetes tipe-1, peningkatan HbA1c lebih disebabkan oleh burnout penyakit daripada pilihan makanan.
Sumber: Nash, C. (2025). doi:10.20944/preprints202511.2324.v1 — Diunggah ulang sesuai lisensi CC BY 4.0. Artikel ini belum melalui peer review.
Sumber: Nash, C. (2025). doi:10.20944/preprints202511.2324.v1 — Diunggah ulang sesuai lisensi CC BY 4.0. Artikel ini belum melalui peer review.
Jurnal
Pre-print
Sociodemographic Determinants of Fruit and Vegetable Consumption in Indonesia: Insights from the 2023 Indonesian Health Survey
Studi cross-sectional ini menganalisis data 595.303 responden dewasa dari Survei Kesehatan Indonesia (SKI) 2023 untuk mengidentifikasi faktor sosiodemografi yang memengaruhi konsumsi buah dan sayur. Hasil menunjukkan 97,1% orang Indonesia tidak memenuhi rekomendasi asupan harian. Konsumsi yang lebih baik ditemukan pada perempuan, individu berpendidikan tinggi, yang bekerja, berstatus menikah, kelompok ekonomi rendah, serta penduduk wilayah Nusa Tenggara, Maluku, Papua, dan pedesaan. Studi ini menekankan perlunya intervensi gizi yang ditargetkan berdasarkan karakteristik sosiodemografi spesifik. Preprint medRxiv — belum melalui peer review. Lisensi CC-BY 4.0. DOI: 10.1101/2025.07.22.25331981
Jurnal
Pre-print